Human megakaryocytes possess intrinsic antiviral immunity through regulated induction of IFITM3

Evolving evidence indicates that platelets and megakaryocytes (MKs) have unexpected activities in inflammation and infection; whether viral infections upregulate biologically active, antiviral immune genes in platelets and MKs is unknown, however. We examined antiviral immune genes in these cells in...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Campbell, Robert A., Schwertz, Hansjorg, Hottz, Eugenio D., Rowley, Jesse W., Manne, Bhanu Kanth, Washington, A. Valance, Hunter-Mellado, Robert, Tolley, Neal D., Christensen, Miles, Eustes, Alicia S., Montenont, Emilie, Bhatlekar, Seema, Ventrone, Cassandra H., Kirkpatrick, Beth D., Pierce, Kristen K., Whitehead, Stephen S., Diehl, Sean A., Bray, Paul F., Zimmerman, Guy A., Kosaka, Yasuhiro, Bozza, Patricia T., Bozza, Fernando A., Weyrich, Andrew S., Rondina, Matthew T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509546/
https://ncbi.nlm.nih.gov/pubmed/30723081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-09-873984
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