Engineered AXL(−ECD)-Fc variants that abolish the AXL/Gas6 interaction suppress tumor cell migration

AXL receptor tyrosine kinase ligand (AXL), a tyrosine kinase receptor that is commonly overexpressed in numerous types of cancer, significantly promotes drug resistance and metastasis in tumor cells. Inhibition of the AXL/growth arrest-specific 6 (Gas6) signaling pathway is emerging as a potential a...

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Pubblicato in:Oncol Lett
Autori principali: Duan, Yanting, Hu, Bo, Qiao, Chunxia, Luo, Longlong, Li, Xinying, Wang, Jing, Liu, Hao, Zhou, Tingting, Shen, Beifen, Lv, Ming, Feng, Jiannan
Natura: Artigo
Lingua:Inglês
Pubblicazione: D.A. Spandidos 2019
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6507473/
https://ncbi.nlm.nih.gov/pubmed/31186805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2019.10255
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