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Investigation of Solvent Hydron Exchange in the Reaction Catalyzed by the Antibiotic Resistance Protein, Cfr

Cfr is a radical S-adenosylmethionine (RS) methylase that appends methyl groups to C8 and C2 of adenosine 2503 in 23S ribosomal RNA. Methylation of C8 confers resistance to several classes of antibiotics that bind in or near the peptidyl transferase center of the bacterial ribosome, including the sy...

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Detalles Bibliográficos
Publicado en:Biochemistry
Main Authors: Bauerle, Matthew R., Grove, Tyler L., Booker, Squire J.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6501181/
https://ncbi.nlm.nih.gov/pubmed/29787246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00347
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