3-deazaneplanocin A protects against cisplatin-induced renal tubular cell apoptosis and acute kidney injury by restoration of E-cadherin expression

3-deazaneplanocin A (3-DZNeP) has been used as an inhibitor of enhancer of zeste homolog 2 (EZH2). Here, we explore the role and underlying mechanisms action of 3-DZNeP in abrogating cisplatin nephrotoxicity. Exposure of cultured mouse renal proximal tubular epithelial cells (mTECs) to cisplatin res...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Ni, Jun, Hou, Xiying, Wang, Xueqiao, Shi, Yinfeng, Xu, Liuqing, Zheng, Xiaoqing, Liu, Na, Qiu, Andong, Zhuang, Shougang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494881/
https://ncbi.nlm.nih.gov/pubmed/31043583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1589-y
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