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Structural basis for ligand modulation of the CCR2 conformational landscape

CC chemokine receptor 2 (CCR2) is a part of the chemokine receptor family, an important class of therapeutic targets. These class A G-protein coupled receptors (GPCRs) are involved in mammalian signaling pathways and control cell migration toward endogenous CC chemokine ligands, named for the adjace...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Taylor, Bryn C., Lee, Christopher T., Amaro, Rommie E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486717/
https://ncbi.nlm.nih.gov/pubmed/30975755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814131116
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