Par-4 overexpression impedes leukemogenesis in the Eµ-TCL1 leukemia model through downregulation of NF-κB signaling

Prostate apoptosis response 4 (Par-4) is a tumor suppressor that prevents proliferation and induces cell death in several solid tumors. However, its role in B-cell malignancies has not been elucidated. To describe the role of Par-4 in chronic lymphocytic leukemia (CLL) pathogenesis, we developed a B...

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Veröffentlicht in:Blood Adv
Hauptverfasser: Greene, J. T., Mani, Rajeswaran, Ramaswamy, Rahul, Frissora, Frank, Yano, Max, Zapolnik, Kevan, Harrington, Bonnie, Wasmuth, Ronni, Tran, Minh, Mo, Xiaokui, McKenna, Mary, Rangnekar, Vivek M., Byrd, John C., Bondada, Subbarao, Muthusamy, Natarajan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2019
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482354/
https://ncbi.nlm.nih.gov/pubmed/30987970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018025973
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