Oscillatory shear potentiates latent TGF-β1 activation more than steady shear as demonstrated by a novel force generator

Cardiovascular mechanical stresses trigger physiological and pathological cellular reactions including secretion of Transforming Growth Factor β1 ubiquitously in a latent form (LTGF-β1). While complex shear stresses can activate LTGF-β1, the mechanisms underlying LTGF-β1 activation remain unclear. W...

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Vydáno v:Sci Rep
Hlavní autoři: Kouzbari, Karim, Hossan, Mohammad R., Arrizabalaga, Julien H., Varshney, Rohan, Simmons, Aaron D., Gostynska, Sandra, Nollert, Matthias U., Ahamed, Jasimuddin
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465594/
https://ncbi.nlm.nih.gov/pubmed/30988341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42302-x
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