Vaccine-induced Antibodies Target Sequestered Viral Antigens to Prevent Ocular HSV-1 Pathogenesis, Preserve Vision, and Preempt Productive Neuronal Infection

The cornea is essential for vision yet highly sensitive to immune-mediated damage following infection. Generating vaccines that provide sterile immunity against ocular surface pathogens without evoking vision loss is therefore clinically challenging. Here, we tested a prophylactic live-attenuated va...

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Detalhes bibliográficos
Publicado no:Mucosal Immunol
Main Authors: Royer, Derek J., Hendrix, Joshua F., Larabee, Chelsea M., Reagan, Alaina M., Sjoelund, Virginie H., Robertson, Danielle M., Carr, Daniel J.J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462227/
https://ncbi.nlm.nih.gov/pubmed/30670763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-019-0131-y
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