Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis

Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, to potentiate Pomc transcription. Deletion of...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Yang, Yongjie, van der Klaauw, Agatha A., Zhu, Liangru, Cacciottolo, Tessa M., He, Yanlin, Stadler, Lukas K. J., Wang, Chunmei, Xu, Pingwen, Saito, Kenji, Hinton, Antentor, Yan, Xiaofeng, Keogh, Julia M., Henning, Elana, Banton, Matthew C., Hendricks, Audrey E., Bochukova, Elena G., Mistry, Vanisha, Lawler, Katherine L., Liao, Lan, Xu, Jianming, O’Rahilly, Stephen, Tong, Qingchun, Inês Barroso, O’Malley, Bert W., Farooqi, I. Sadaf, Xu, Yong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461669/
https://ncbi.nlm.nih.gov/pubmed/30979869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08737-6
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