Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance

Autophagy maintains homeostasis and is induced upon stress. Yet, its mechanistic interaction with oncogenic signaling remains elusive. Here, we show that in BRAF(V600E)-melanoma, autophagy is induced by BRAF inhibitor (BRAFi), as part of a transcriptional program coordinating lysosome biogenesis/fun...

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Publicat a:Nat Commun
Autors principals: Li, Shun, Song, Ying, Quach, Christine, Guo, Hongrui, Jang, Gyu-Beom, Maazi, Hadi, Zhao, Shihui, Sands, Nathaniel A., Liu, Qingsong, In, Gino K., Peng, David, Yuan, Weiming, Machida, Keigo, Yu, Min, Akbari, Omid, Hagiya, Ashley, Yang, Yongfei, Punj, Vasu, Tang, Liling, Liang, Chengyu
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461621/
https://ncbi.nlm.nih.gov/pubmed/30979895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09634-8
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