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40.3 TARGETING NMDAR HYPOFUNCTION DURING EARLY DEVELOPMENT FOR THE PREVENTION OF SCHIZOPHRENIA PHENOTYPES IN ADULTHOOD IN THE MAM MODEL

BACKGROUND: Glutamate hypofunction has been a prominent hypothesis in the understanding of schizophrenia (SCZ) pathology. Particularly, the N-methyl-D-aspartate receptor (NMDAR), a major glutamate receptor subtype, demonstrates alterations in post-mortem studies, and prefrontal glutamatergic hypofun...

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Publicat a:Schizophr Bull
Autors principals: Gao, Wen-Jun, Xing, Bo, Li, Meng-lin, Gulchina, Yelena
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6455813/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/schbul/sbz022.166
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