Acoustic tweezing cytometry for mechanical phenotyping of macrophages and mechanopharmaceutical cytotripsy

Macrophages are immune cells responsible for tissue debridement and fighting infection. Clofazimine, an FDA-approved antibiotic, accumulates and precipitates as rod-shaped, crystal-like drug inclusions within macrophage lysosomes. Drug treatment as well as pathophysiological states could induce chan...

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Udgivet i:Sci Rep
Main Authors: Hong, Xiaowei, Rzeczycki, Phillip M., Keswani, Rahul K., Murashov, Mikhail D., Fan, Zhenzhen, Deng, Cheri X., Rosania, Gus R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450871/
https://ncbi.nlm.nih.gov/pubmed/30952950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42180-3
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