Tuberculosis drugs’ distribution and emergence of resistance in patient’s lung lesions: A mechanistic model and tool for regimen and dose optimization

BACKGROUND: The sites of mycobacterial infection in the lungs of tuberculosis (TB) patients have complex structures and poor vascularization, which obstructs drug distribution to these hard-to-reach and hard-to-treat disease sites, further leading to suboptimal drug concentrations, resulting in comp...

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Udgivet i:PLoS Med
Main Authors: Strydom, Natasha, Gupta, Sneha V., Fox, William S., Via, Laura E., Bang, Hyeeun, Lee, Myungsun, Eum, Seokyong, Shim, TaeSun, Barry, Clifton E., Zimmerman, Matthew, Dartois, Véronique, Savic, Radojka M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445413/
https://ncbi.nlm.nih.gov/pubmed/30939136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1002773
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