Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution

Genome-wide association studies (GWAS) have identified multiple associations with emphysema apicobasal distribution (EABD), but the biological functions of these variants are unknown. To characterize the functions of EABD-associated variants, we integrated GWAS results with 1) expression quantitativ...

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Vydáno v:Am J Respir Cell Mol Biol
Hlavní autoři: Boueiz, Adel, Pham, Betty, Chase, Robert, Lamb, Andrew, Lee, Sool, Naing, Zun Zar Chi, Cho, Michael H., Parker, Margaret M., Sakornsakolpat, Phuwanat, Hersh, Craig P., Crapo, James D., Stergachis, Andrew B., Tal-Singer, Ruth, DeMeo, Dawn L., Silverman, Edwin K., Zhou, Xiaobo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2019
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6444627/
https://ncbi.nlm.nih.gov/pubmed/30335480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2018-0110OC
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