YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis in Vivo

Specialized adult somatic cells, such as cardiomyocytes (CMs), are highly differentiated with poor renewal capacity, an integral reason underlying organ failure in disease and aging. Among the least renewable cells in the human body, CMs renew approximately 1% annually. Consistent with poor CM turno...

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Gepubliceerd in:Dev Cell
Hoofdauteurs: Monroe, Tanner O., Hill, Matthew C., Morikawa, Yuka, Leach, John P., Heallen, Todd, Cao, Shuyi, Krijger, Peter H. L., de Laat, Wouter, Wehrens, Xander H.T., Rodney, George G., Martin, James F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6435425/
https://ncbi.nlm.nih.gov/pubmed/30773489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.01.017
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