Hookworm-Derived Metabolites Suppress Pathology in a Mouse Model of Colitis and Inhibit Secretion of Key Inflammatory Cytokines in Primary Human Leukocytes

Iatrogenic hookworm therapy shows promise for treating disorders that result from a dysregulated immune system, including inflammatory bowel disease (IBD). Using a murine model of trinitrobenzenesulfonic acid-induced colitis and human peripheral blood mononuclear cells, we demonstrated that low-mole...

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Udgivet i:Infect Immun
Main Authors: Wangchuk, Phurpa, Shepherd, Catherine, Constantinoiu, Constantin, Ryan, Rachael Y. M., Kouremenos, Konstantinos A., Becker, Luke, Jones, Linda, Buitrago, Geraldine, Giacomin, Paul, Wilson, David, Daly, Norelle, McConville, Malcolm J., Miles, John J., Loukas, Alex
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Fungal and Parasitic Infections
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6434117/
https://ncbi.nlm.nih.gov/pubmed/30670556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00851-18
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