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Aggrecan Hypomorphism Compromises Articular Cartilage Biomechanical Properties and Is Associated with Increased Incidence of Spontaneous Osteoarthritis

The gene encoding the proteoglycan aggrecan (Agc1) is abundantly expressed in cartilage during development and adulthood, and the loss or diminished deposition of the protein results in a wide range of skeletal malformations. Furthermore, aggrecan degradation is a hallmark of cartilage degeneration...

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Bibliografske podrobnosti
izdano v:Int J Mol Sci
Main Authors: Alberton, Paolo, Dugonitsch, Hans Christian, Hartmann, Bastian, Li, Ping, Farkas, Zsuzsanna, Saller, Maximilian Michael, Clausen-Schaumann, Hauke, Aszodi, Attila
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6429589/
https://ncbi.nlm.nih.gov/pubmed/30813547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20051008
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