Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signaling

Transferrin receptor 2 (Tfr2) is mainly expressed in the liver and controls iron homeostasis. Here, we identify Tfr2 as a regulator of bone homeostasis that inhibits bone formation. Mice lacking Tfr2 display increased bone mass and mineralization independent of iron homeostasis and hepatic Tfr2. Bon...

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Gepubliceerd in:Nat Metab
Hoofdauteurs: Rauner, Martina, Baschant, Ulrike, Roetto, Antonella, Pellegrino, Rosa Maria, Rother, Sandra, Salbach-Hirsch, Juliane, Weidner, Heike, Hintze, Vera, Campbell, Graeme, Petzold, Andreas, Lemaitre, Regis, Henry, Ian, Bellido, Teresita, Theurl, Igor, Altamura, Sandro, Colucci, Silvia, Muckenthaler, Martina U., Schett, Georg, Komla Ebri, Davide, Bassett, J. H. Duncan, Williams, Graham R., Platzbecker, Uwe, Hofbauer, Lorenz C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420074/
https://ncbi.nlm.nih.gov/pubmed/30886999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-018-0005-8
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