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A simple model to solve a complex drug toxicity problem
Linear drug toxicity models like therapeutic index (TI), physicochemical rules (rule of five, 3/75), ligand efficiency indices (LEI), ideal pharmacokinetic (PK) and pharmacodynamic (PD) profiles are widely used in drug discovery and development. In spite of this, predicting drug toxicity at various...
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| Gepubliceerd in: | Toxicol Res (Camb) |
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| Hoofdauteur: | |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Royal Society of Chemistry
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6417485/ https://ncbi.nlm.nih.gov/pubmed/30997019 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8tx00261d |
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