Indoxyl Sulfate Induces Apoptosis through Oxidative Stress and Mitogen-Activated Protein Kinase Signaling Pathway Inhibition in Human Astrocytes

Uremic toxins accumulated in chronic kidney disease (CKD) increases the risk of cognitive impairment. Indoxyl sulfate (IS) is a well-known protein-bound uremic toxin that is correlated with several systemic diseases, but no studies on human brain cells are available. We investigated the effect of IS...

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Publicado no:J Clin Med
Main Authors: Lin, Yi-Ting, Wu, Ping-Hsun, Tsai, Yi-Chun, Hsu, Ya-Ling, Wang, Han Ying, Kuo, Mei-Chuan, Kuo, Po-Lin, Hwang, Shang-Jyh
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6406290/
https://ncbi.nlm.nih.gov/pubmed/30764571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm8020191
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