Evaluation and Optimization of Pharmacokinetic Models for in Vitro to in Vivo Extrapolation of Estrogenic Activity for Environmental Chemicals

BACKGROUND: To effectively incorporate in vitro data into regulatory use, confidence must be established in the quantitative extrapolation of in vitro activity to relevant end points in animals or humans. OBJECTIVE: Our goal was to evaluate and optimize in vitro to in vivo extrapolation (IVIVE) appr...

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Bibliographische Detailangaben
Veröffentlicht in:Environ Health Perspect
Hauptverfasser: Casey, Warren M., Chang, Xiaoqing, Allen, David G., Ceger, Patricia C., Choksi, Neepa Y., Hsieh, Jui-Hua, Wetmore, Barbara A., Ferguson, Stephen S., DeVito, Michael J., Sprankle, Catherine S., Kleinstreuer, Nicole C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Environmental Health Perspectives 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6375436/
https://ncbi.nlm.nih.gov/pubmed/30192161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/EHP1655
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