Identification of the novel Ido1 imprinted locus and its potential epigenetic role in pregnancy loss

Previous studies show that aberrant tryptophan catabolism reduces maternal immune tolerance and adversely impacts pregnancy outcomes. Tryptophan depletion in pregnancy is facilitated by increased activity of tryptophan-depleting enzymes [i.e. the indolamine-2,3 dioxygenase (IDO)1 and IDO2) in the pl...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Spinelli, Philip, Latchney, Sarah E, Reed, Jasmine M, Fields, Ashley, Baier, Brian S, Lu, Xiang, McCall, Matthew N, Murphy, Shawn P, Mak, Winifred, Susiarjo, Martha
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
General Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360327/
https://ncbi.nlm.nih.gov/pubmed/30403776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy383
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