Identification of the novel Ido1 imprinted locus and its potential epigenetic role in pregnancy loss

Previous studies show that aberrant tryptophan catabolism reduces maternal immune tolerance and adversely impacts pregnancy outcomes. Tryptophan depletion in pregnancy is facilitated by increased activity of tryptophan-depleting enzymes [i.e. the indolamine-2,3 dioxygenase (IDO)1 and IDO2) in the pl...

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Bibliographic Details
Published in:Hum Mol Genet
Main Authors: Spinelli, Philip, Latchney, Sarah E, Reed, Jasmine M, Fields, Ashley, Baier, Brian S, Lu, Xiang, McCall, Matthew N, Murphy, Shawn P, Mak, Winifred, Susiarjo, Martha
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
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General Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360327/
https://ncbi.nlm.nih.gov/pubmed/30403776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy383
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