Cyclooxygenase-2 inhibition potentiates the efficacy of vascular endothelial growth factor blockade and promotes an immune stimulatory microenvironment in preclinical models of pancreatic cancer

Resistance to standard therapy remains a major challenge in the treatment of pancreatic ductal adenocarcinoma (PDA). Although anti-VEGF therapy delays PDA progression, therapy-induced hypoxia results in a less differentiated mesenchymal-like tumor cell phenotype, which reinforces the need for effect...

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Pubblicato in:Mol Cancer Res
Autori principali: Zhang, Yuqing, Kirane, Amanda, Huang, Huocong, Sorrelle, Noah B., Burrows, Francis J., Dellinger, Michael T., Brekken, Rolf A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6359969/
https://ncbi.nlm.nih.gov/pubmed/30333153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-0427
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