α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson’s disease

A compelling link is emerging between the posttranslational modification O-GlcNAc and protein aggregation. A prime example is α-synuclein, which forms toxic aggregates that are associated with neurodegeneration in Parkinson’s and related diseases. α-Synuclein has been shown to be O-GlcNAcylated at n...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Levine, Paul M., Galesic, Ana, Balana, Aaron T., Mahul-Mellier, Anne-Laure, Navarro, Mariana X., De Leon, Cesar A., Lashuel, Hilal A., Pratt, Matthew R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358670/
https://ncbi.nlm.nih.gov/pubmed/30651314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808845116
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