A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats

We previously demonstrated that beta II protein kinase C (βIIPKC) activity is elevated in failing hearts and contributes to this pathology. Here we report that βIIPKC accumulates on the mitochondrial outer membrane and phosphorylates mitofusin 1 (Mfn1) at serine 86. Mfn1 phosphorylation results in p...

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Publicat a:Nat Commun
Autors principals: Ferreira, Julio C. B., Campos, Juliane C., Qvit, Nir, Qi, Xin, Bozi, Luiz H. M., Bechara, Luiz R. G., Lima, Vanessa M., Queliconi, Bruno B., Disatnik, Marie-Helene, Dourado, Paulo M. M., Kowaltowski, Alicia J., Mochly-Rosen, Daria
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338754/
https://ncbi.nlm.nih.gov/pubmed/30659190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08276-6
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