New mtDNA Association Model, MutPred Variant Load, Suggests Individuals With Multiple Mildly Deleterious mtDNA Variants Are More Likely to Suffer From Atherosclerosis

The etiology of common complex diseases is multifactorial, involving both genetic, and environmental factors. A role for mitochondrial dysfunction and mitochondrial DNA (mtDNA) variation has been suggested in the pathogenesis of common complex traits. The aim of this study was to investigate a poten...

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Detalles Bibliográficos
Publicado en:Front Genet
Autores principales: Piotrowska-Nowak, Agnieszka, Elson, Joanna L., Sobczyk-Kopciol, Agnieszka, Piwonska, Aleksandra, Puch-Walczak, Aleksandra, Drygas, Wojciech, Ploski, Rafal, Bartnik, Ewa, Tonska, Katarzyna
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Genetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6332467/
https://ncbi.nlm.nih.gov/pubmed/30671084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2018.00702
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