New mtDNA Association Model, MutPred Variant Load, Suggests Individuals With Multiple Mildly Deleterious mtDNA Variants Are More Likely to Suffer From Atherosclerosis

The etiology of common complex diseases is multifactorial, involving both genetic, and environmental factors. A role for mitochondrial dysfunction and mitochondrial DNA (mtDNA) variation has been suggested in the pathogenesis of common complex traits. The aim of this study was to investigate a poten...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Piotrowska-Nowak, Agnieszka, Elson, Joanna L., Sobczyk-Kopciol, Agnieszka, Piwonska, Aleksandra, Puch-Walczak, Aleksandra, Drygas, Wojciech, Ploski, Rafal, Bartnik, Ewa, Tonska, Katarzyna
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6332467/
https://ncbi.nlm.nih.gov/pubmed/30671084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2018.00702
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