Metabolic regulation of pluripotency and germ cell fate through α‐ketoglutarate

An intricate link is becoming apparent between metabolism and cellular identities. Here, we explore the basis for such a link in an in vitro model for early mouse embryonic development: from naïve pluripotency to the specification of primordial germ cells (PGCs). Using single‐cell RNA‐seq with stati...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Tischler, Julia, Gruhn, Wolfram H, Reid, John, Allgeyer, Edward, Buettner, Florian, Marr, Carsten, Theis, Fabian, Simons, Ben D, Wernisch, Lorenz, Surani, M Azim
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6315289/
https://ncbi.nlm.nih.gov/pubmed/30257965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899518
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