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High throughput screening against pantothenate synthetase identifies amide inhibitors against Mycobacterium tuberculosis and Staphylococcus aureus

ABSTRACT: Pantothenate is a crucial enzyme for the synthesis of coenzyme A and acyl carrier protein in Mycobacterium tuberculosis and Staphylococcus aureus. It is indispensable for the growth and survival of these bacteria. Amides analogs are designed and have been used as inhibitors of pantothenate...

詳細記述

保存先:
書誌詳細
出版年:In Silico Pharmacol
主要な著者: Pradhan, Sayantan, Sinha, Chittaranjan
フォーマット: Artigo
言語:Inglês
出版事項: Springer Berlin Heidelberg 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314788/
https://ncbi.nlm.nih.gov/pubmed/30607322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40203-018-0046-4
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