Identification of Inhibitory Ca(2+) Binding Sites in the Upper Vestibule of the Yeast Vacuolar TRP Channel

By vacuolar patch-clamp and Ca(2+) imaging experiments, we show that the yeast vacuolar transient receptor potential (TRPY) channel 1 is activated by cytosolic Ca(2+) and inhibited by Ca(2+) from the vacuolar lumen. The channel is cooperatively affected by vacuolar Ca(2+) (Hill coefficient, 1.5), su...

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Publicado en:iScience
Autores principales: Amini, Mahnaz, Wang, Hongmei, Belkacemi, Anouar, Jung, Martin, Bertl, Adam, Schlenstedt, Gabriel, Flockerzi, Veit, Beck, Andreas
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6299153/
https://ncbi.nlm.nih.gov/pubmed/30572205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.11.037
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