Transcriptional Approach for Decoding the Mechanism of rpoC Compensatory Mutations for the Fitness Cost in Rifampicin-Resistant Mycobacterium tuberculosis

Multidrug-resistant tuberculosis (TB), defined as TB resistant to the two first-line drugs, isoniazid and rifampin, is a serious challenge to global TB eradication efforts. Although mutations in rpoA or rpoC have been proposed to compensate for this fitness cost due to rpoB mutation in rifampicin-re...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Xu, Zhihong, Zhou, Aiping, Wu, Jiawei, Zhou, Aiwu, Li, Jun, Zhang, Shulin, Wu, Wenjuan, Karakousis, Petros C., Yao, Yu-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283890/
https://ncbi.nlm.nih.gov/pubmed/30555440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.02895
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