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Synthesis and Pharmacological Evaluation of Novel Pleuromutilin Derivatives with Substituted Benzimidazole Moieties

A series of novel pleuromutilin derivatives with substituted benzimidazole moieties were designed and synthesized from pleuromutilin and 5-amino-2-mercaptobenzimidazole through sequential reactions. All the newly synthesized compounds were characterized by IR, NMR, and HRMS. Each of the derivatives...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Ai, Xin, Pu, Xiuying, Yi, Yunpeng, Liu, Yu, Xu, Shuijin, Liang, Jianping, Shang, Ruofeng
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273978/
https://ncbi.nlm.nih.gov/pubmed/27834819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21111488
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