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A QM/MM–Based Computational Investigation on the Catalytic Mechanism of Saccharopine Reductase
Saccharopine reductase from Magnaporthe grisea, an NADPH-containing enzyme in the α-aminoadipate pathway, catalyses the formation of saccharopine, a precursor to L-lysine, from the substrates glutamate and α-aminoadipate-δ-semialdehyde. Its catalytic mechanism has been investigated using quantum mec...
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| Publicado no: | Molecules |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6264447/ https://ncbi.nlm.nih.gov/pubmed/21993247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules16108569 |
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