Patient-derived tumor immune microenvironments in patient-derived xenografts of lung cancer

BACKGROUND: Because patient-derived xenografts (PDXs) are grown in immunodeficient mouse strains, PDXs are regarded as lacking an immune microenvironment. However, whether patients’ immune cells co-exist in PDXs remains uncharacterized. METHODS: We cultured small pieces of lung PDX tissue in media c...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Pu, Xingxiang, Zhang, Ran, Wang, Li, Chen, Yungchang, Xu, Yi, Pataer, Apar, Meraz, Ismail M., Zhang, Xiaoshan, Wu, Shuhong, Wu, Lin, Su, Dan, Mao, Weimin, Heymach, John V., Roth, Jack A., Swisher, Stephen G., Fang, Bingliang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6260563/
https://ncbi.nlm.nih.gov/pubmed/30477533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-018-1704-3
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