High-throughput T cell receptor sequencing identifies clonally expanded CD8(+) T cell populations in alopecia areata

Alopecia areata (AA) is an autoimmune disease in which cytotoxic T cells specifically target growing hair follicles. We used high-throughput TCR sequencing in the C3H/HeJ mouse model of AA and in human AA patients to gain insight into pathogenic T cell populations and their dynamics, which revealed...

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Foilsithe in:JCI Insight
Main Authors: de Jong, Annemieke, Jabbari, Ali, Dai, Zhenpeng, Xing, Luzhou, Lee, Dustin, Li, Mei Mei, Duvic, Madeleine, Hordinsky, Maria, Norris, David A., Price, Vera, Mackay-Wiggan, Julian, Clynes, Raphael, Christiano, Angela M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2018
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237451/
https://ncbi.nlm.nih.gov/pubmed/30282836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121949
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