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Are you TORCing tau me? Amyloid‐β blocks the conversation between lysosomes and mitochondria

How amyloid‐β (Aβ) and tau exacerbate Alzheimer's disease (AD) at a subcellular level is only incompletely understood. Norambuena et al (2018) report crosstalk between mitochondria and lysosomes and identify a role for lysosomal mTORC1 in the nutrient‐induced activation of mitochondria. This ly...

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Détails bibliographiques
Publié dans:EMBO J
Auteurs principaux: Polanco, Juan Carlos, Götz, Jürgen
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6236328/
https://ncbi.nlm.nih.gov/pubmed/30389662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100839
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