Analysis of the Binding of Aripiprazole to Human Serum Albumin: The Importance of a Chloro-Group in the Chemical Structure

[Image: see text] Aripiprazole (ARP), a quinolinone derivative, is an atypical antipsychotic drug that is used in the treatment of schizophrenia. ARP has an extensive distribution and more than 99% of the ARP and dehydro-ARP, the main active metabolite, is bound to plasma proteins. However, informat...

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Publicado en:ACS Omega
Autores principales: Sakurama, Keiki, Kawai, Akito, Tuan Giam Chuang, Victor, Kanamori, Yoko, Osa, Miyu, Taguchi, Kazuaki, Seo, Hakaru, Maruyama, Toru, Imoto, Shuhei, Yamasaki, Keishi, Otagiri, Masaki
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2018
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217653/
https://ncbi.nlm.nih.gov/pubmed/30411049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b02057
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