Semimechanistic Population Pharmacokinetic Model to Predict the Drug–Drug Interaction Between S‐ketamine and Ticlopidine in Healthy Human Volunteers

Low‐dose oral S‐ketamine is increasingly used in chronic pain therapy, but extensive cytochrome P450 (CYP) mediated metabolism makes it prone to pharmacokinetic drug‐drug interactions (DDIs). In our study, concentration‐time data from five studies were used to develop a semimechanistic model that de...

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Foilsithe in:CPT Pharmacometrics Syst Pharmacol
Main Authors: Ashraf, Muhammad W., Peltoniemi, Marko A., Olkkola, Klaus T., Neuvonen, Pertti J., Saari, Teijo I.
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2018
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202471/
https://ncbi.nlm.nih.gov/pubmed/30091858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12346
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