Exploring Crimean-Congo Hemorrhagic Fever Virus-Induced Hepatic Injury Using Antibody-Mediated Type I Interferon Blockade in Mice

Crimean-Congo hemorrhagic fever virus (CCHFV) can cause severe hepatic injury in humans. However, the mechanism(s) causing this damage is poorly characterized. CCHFV produces an acute disease, including liver damage, in mice lacking type I interferon (IFN-I) signaling due to either STAT-1 gene delet...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Lindquist, Michael E., Zeng, Xiankun, Altamura, Louis A., Daye, Sharon P., Delp, Korey L., Blancett, Candace, Coffin, Kayla M., Koehler, Jeffrey W., Coyne, Susan, Shoemaker, Charles J., Garrison, Aura R., Golden, Joseph W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6189508/
https://ncbi.nlm.nih.gov/pubmed/30111561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01083-18
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