Effect of Biphenyl Hydrolase-Like (BPHL) Gene Disruption on the Intestinal Stability, Permeability and Absorption of Valacyclovir in Wildtype and Bphl Knockout Mice

Biphenyl hydrolase-like protein (BPHL) is a novel human serine hydrolase that was originally cloned from a breast carcinoma cDNA library and shown to convert valacyclovir to acyclovir and valganciclovir to ganciclovir. However, the exclusivity of this process has not been determined and, indeed, it...

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Vydáno v:Biochem Pharmacol
Hlavní autoři: Hu, Yongjun, Epling, Daniel, Shi, Jian, Song, Feifeng, Tsume, Yasuhiro, Zhu, Hao-Jie, Amidon, Gordon L., Smith, David E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6188833/
https://ncbi.nlm.nih.gov/pubmed/30121252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2018.08.018
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