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Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain
Synaptic dysfunction and loss are core pathological features in Alzheimer disease (AD). In the vicinity of amyloid-β plaques in animal models, synaptic toxicity occurs and is associated with chronic activation of the phosphatase calcineurin (CN). Indeed, pharmacological inhibition of CN blocks amylo...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Neurochem |
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| Κύριοι συγγραφείς: | , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6181788/ https://ncbi.nlm.nih.gov/pubmed/29806693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.14469 |
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