Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain

Synaptic dysfunction and loss are core pathological features in Alzheimer disease (AD). In the vicinity of amyloid-β plaques in animal models, synaptic toxicity occurs and is associated with chronic activation of the phosphatase calcineurin (CN). Indeed, pharmacological inhibition of CN blocks amylo...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Neurochem
Hlavní autoři: Hopp, Sarah C., Bihlmeyer, Nathan A., Corradi, John P., Vanderburg, Charles, Cacace, Angela M., Das, Sudeshna, Clark, Timothy W., Betensky, Rebecca A., Hyman, Bradley T., Hudry, Eloise
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6181788/
https://ncbi.nlm.nih.gov/pubmed/29806693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.14469
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky