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Developmental stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors
Most retinoblastomas initiate in response to the inactivation of the RB1 gene and loss of functional RB protein. The tumors may form with few additional genomic changes and develop after a premalignant retinoma phase. Despite this seemingly straightforward etiology, mouse models have not recapitulat...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6176579/ https://ncbi.nlm.nih.gov/pubmed/30213853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808903115 |
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