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Developmental stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors
Most retinoblastomas initiate in response to the inactivation of the RB1 gene and loss of functional RB protein. The tumors may form with few additional genomic changes and develop after a premalignant retinoma phase. Despite this seemingly straightforward etiology, mouse models have not recapitulat...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6176579/ https://ncbi.nlm.nih.gov/pubmed/30213853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808903115 |
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