Developmental stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors

Most retinoblastomas initiate in response to the inactivation of the RB1 gene and loss of functional RB protein. The tumors may form with few additional genomic changes and develop after a premalignant retinoma phase. Despite this seemingly straightforward etiology, mouse models have not recapitulat...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Singh, Hardeep P., Wang, Sijia, Stachelek, Kevin, Lee, Sunhye, Reid, Mark W., Thornton, Matthew E., Craft, Cheryl Mae, Grubbs, Brendan H., Cobrinik, David
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6176579/
https://ncbi.nlm.nih.gov/pubmed/30213853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808903115
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