Toll‐Like Receptor 9 Deficiency Breaks Tolerance to RNA‐Associated Antigens and Up‐Regulates Toll‐Like Receptor 7 Protein in Sle1 Mice

OBJECTIVE: Toll‐like receptors (TLRs) 7 and 9 are important innate signaling molecules with opposing roles in the development and progression of systemic lupus erythematosus (SLE). While multiple studies support the notion of a dependency on TLR‐7 for disease development, genetic ablation of TLR‐9 r...

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Detalhes bibliográficos
Publicado no:Arthritis Rheumatol
Main Authors: Celhar, Teja, Yasuga, Hiroko, Lee, Hui Yin, Zharkova, Olga, Tripathi, Shubhita, Thornhill, Susannah I., Lu, Hao K., Au, Bijin, Lim, Lina H. K., Thamboo, Thomas P., Akira, Shizuo, Wakeland, Edward K., Connolly, John E., Fairhurst, Anna‐Marie
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Systemic Lupus Erythematosus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175219/
https://ncbi.nlm.nih.gov/pubmed/29687651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40535
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