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M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry

Macrophage plasticity is essential for innate immunity, but in-depth signaling mechanism(s) regulating their functional phenotypes are ill-defined. Here we report that interferon (IFN) γ priming of naive macrophages induces store-mediated Ca(2+) entry and inhibition of Ca(2+) entry impairs polarizat...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Chauhan, Arun, Sun, Yuyang, Sukumaran, Pramod, Quenum Zangbede, Fredice O., Jondle, Christopher N., Sharma, Atul, Evans, Dustin L., Chauhan, Pooja, Szlabick, Randolph E., Aaland, Mary O., Birnbaumer, Lutz, Sharma, Jyotika, Singh, Brij B., Mishra, Bibhuti B.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6174824/
https://ncbi.nlm.nih.gov/pubmed/30293012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.09.014
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