AS03-adjuvanted H5N1 vaccine promotes antibody diversity and affinity maturation, NAI titers, cross-clade H5N1 neutralization, but not H1N1 cross-subtype neutralization

Immune responses to inactivated vaccines against avian influenza are poor due in part to lack of immune memory. Adjuvants significantly increased virus neutralizing titers. We performed comprehensive analyses of polyclonal antibody responses following FDA-approved adjuvanted H5N1-A/Indonesia vaccine...

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Detalhes bibliográficos
Publicado no:NPJ Vaccines
Main Authors: Khurana, Surender, Coyle, Elizabeth M., Manischewitz, Jody, King, Lisa R., Gao, Jin, Germain, Ronald N., Schwartzberg, Pamela L., Tsang, John S., Golding, Hana
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6167326/
https://ncbi.nlm.nih.gov/pubmed/30302282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-018-0076-2
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