Gelatinase B/matrix metalloproteinase-9 is a phase-specific effector molecule, independent from Fas, in experimental autoimmune encephalomyelitis

Gelatinase B/matrix metalloproteinase-9 (MMP-9) triggers multiple sclerosis (MS) and the animal model of experimental autoimmune encephalomyelitis (EAE) by the breakdown of the blood-brain barrier. Interestingly, MMP-9 is beneficial in systemic autoimmunity caused by Fas-deficiency. Fas-deficient (f...

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Bibliographic Details
Published in:PLoS One
Main Authors: Ugarte-Berzal, Estefania, Berghmans, Nele, Boon, Lise, Martens, Erik, Vandooren, Jennifer, Cauwe, Bénédicte, Thijs, Greet, Proost, Paul, Van Damme, Jo, Opdenakker, Ghislain
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166937/
https://ncbi.nlm.nih.gov/pubmed/30273366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197944
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